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@Donald_Zimmerman Hi and welcome, If it is a Random friend who you do not know it is not possible to remove them from your game. If you know the person you can delete from you friends list. All it is possible to do is stop all facebook notifications but this will stop them all. i tend just to accept all and send as they will only receive 1 life from you per day or try to ignore them and hopefully they eventually give up sending so many or realize they only get 1 life a day.
Not the greatest option but think better to have free lives in the game than not having the option at all
Thank you