I like the color bomb. Put two of those babies together and watch the magic. Put it with a wrapped candy or striped candy and another kind of magic happens.
The color bomb is probably the most used alone or in multiple combinations, the lollipop hammer would be next giving you the ability to destroy targets and keys that are out of range and the free switch is also handy!
My most used booster is the paint brush. I like it the most because I can use it for everything and every event. It's also the least to get when you are playing.