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Of course they can be hit, although it's not absolutely necessary to clear all of them to win anyway. A colourbomb in combination with striped candy gives you a greatly increased chance; a colourbomb in combination with a wrapped candy where a candy of the same colour is in contact will give you two hits; a colourbomb x2 combination will give you a hit on all four. If that fails then the coconut wheel booster is ideal for picking up the hard to reach corners (easily obtained for free).