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First try blasting the mixers out of the way, usually takes three or four hits to get rid of them and the +5s will come down while you're doing that. unfortunately once all of your +5s are gone they don't drop anymore down. So now you have to make good combos like a package any stripe or a chocolate ball and a stripe you'll get there eventually but it just sucks that they don't drop any more +5s you just have to get lucky and make some good combos. Good luck!!